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首页> 外文OA文献 >CIPRO 2.5: Ciona intestinalis protein database, a unique integrated repository of large-scale omics data, bioinformatic analyses and curated annotation, with user rating and reviewing functionality
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CIPRO 2.5: Ciona intestinalis protein database, a unique integrated repository of large-scale omics data, bioinformatic analyses and curated annotation, with user rating and reviewing functionality

机译：CIPRO 2.5：Ciona小肠蛋白质数据库，一个独特的集成数据库，用于大规模组学数据，生物信息学分析和精选注释，具有用户评分和审阅功能

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The Ciona intestinalis protein database (CIPRO) is an integrated protein database for the tunicate species C. intestinalis. The database is unique in two respects: first, because of its phylogenetic position, Ciona is suitable model for understanding vertebrate evolution; and second, the database includes original large-scale transcriptomic and proteomic data. Ciona intestinalis has also been a favorite of developmental biologists. Therefore, large amounts of data exist on its development and morphology, along with a recent genome sequence and gene expression data. The CIPRO database is aimed at collecting those published data as well as providing unique information from unpublished experimental data, such as 3D expression profiling, 2D-PAGE and mass spectrometry-based large-scale analyses at various developmental stages, curated annotation data and various bioinformatic data, to facilitate research in diverse areas, including developmental, comparative and evolutionary biology. For medical and evolutionary research, homologs in humans and major model organisms are intentionally included. The current database is based on a recently developed KH model containing 36 034 unique sequences, but for higher usability it covers 89 683 all known and predicted proteins from all gene models for this species. Of these sequences, more than 10 000 proteins have been manually annotated. Furthermore, to establish a community-supported protein database, these annotations are open to evaluation by users through the CIPRO website. CIPRO 2.5 is freely accessible at http://cipro.ibio.jp/2.5.
机译：Ciona intestinalis蛋白数据库（CIPRO）是被膜种C. intestinalis的综合蛋白数据库。该数据库在两个方面是独一无二的：首先，由于其系统发育的位置，Ciona是理解脊椎动物进化的合适模型；第二，数据库包含原始的大规模转录组和蛋白质组数据。肠纳豆（Ciona intestinalis）也一直是发育生物学家的最爱。因此，关于其发展和形态的大量数据，以及最近的基因组序列和基因表达数据。 CIPRO数据库旨在收集那些已发布的数据，并提供来自未发布的实验数据的独特信息，例如在各个开发阶段的3D表达谱，2D-PAGE和基于质谱的大规模分析，精选注释数据和各种生物信息学数据，以促进在不同领域的研究，包括发育，比较和进化生物学。对于医学和进化研究，有意包括人类和主要模式生物的同源物。当前数据库基于最近开发的包含36-034个独特序列的KH模型，但出于更高的可用性，它涵盖了89-683个该物种所有基因模型中所有已知和预测的蛋白质。在这些序列中，已经人工注释了10 000多种蛋白质。此外，要建立一个社区支持的蛋白质数据库，这些注释将开放给用户通过CIPRO网站进行评估。可以从http://cipro.ibio.jp/2.5免费访问CIPRO 2.5。

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